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More than a year after its disastrous debut, the federal website HealthCare.gov reopened last night, giving shoppers a few days to browse ahead of the November 15 start date for open enrollment, when consumers will have 60 days to make changes or, for some, select first-time coverage under the Affordable Care Act.

The FDA Oncologic Drugs Advisory Committee voted against recommending panobinostat plus bortezomib and dexamethasone for patients with previously treated multiple myeloma.

In less than 2 months the health insurance Marketplaces will need to be financially self-sustaining, which will occur through a variety of approaches, as federal establishment funds will run out on January 1, 2015.

The treatment, conducted at the University of Pennsylvania, identified a mutation in the BRaf gene which is commonly mutated in melanoma. Subsequent treatment with dabrafenib and trametinib resulted in rapid tumor shrinkage.

Based on data from 17 states and the District of Columbia, premium increases for 2015 are expected to be low, according to a report from The Urban Institute.

On the heels of a major Republican victory in the midterm elections, the Supreme Court has decided to review the latest challenge to the Affordable Care Act.

The study results from the National Lung Screening Trial found cost-effectiveness and value of screening long-term smokers when screened by trained professionals.

Three days after the Republican Party gained control of the US Senate and rose to 250 seats in the House of Representatives, the airwaves are filled with bluster aimed at respective bases over what will become of the Affordable Care Act (ACA). While experts from both sides of the aisle agree that a full repeal is unlikely, 1 item has shown up on almost every early list of elements unlikely to survive the next Congress: the medical device tax.

Transferring New Hampshire's Medicaid program to so-called managed care is a huge, sprawling puzzle, and part of the program is being delayed.

Despite numerous delays and the difficulty of preparing for ICD-10, there are reasons to be optimistic for the transition, according to the results of a new survey.

Ileana Arias, PhD, CDC principal deputy director, recommends active screening by Pap test and HPV test, and vaccination of young boys and girls to improve early detection and prevention rates.

The so-called "Mediterranean diet" has long been recommended as a way to control weight and prevent diabetes. Now, the American Heart Association and the American Stroke Association have issued new guidelines that say the diet should be encouraged to reduce a person's risk of first-time stroke.

The drug combination showed a significant improvement of 2.2 months in OS compared to the placebo arm.

Recently released numbers from the CMS Meaningful Use program were lower than expected, which further highlights the changes that need to be made in meeting federal guidelines for electronic health record requirements, according to officials 4 healthcare organizations.

The study, published in the New England Journal of Medicine, found that using the I-PASS communication system for patient hand-off between providers significantly reduced patient injuries due to medical errors.

A special report on what the historic election of Republicans in races for the Senate, US House of Representatives, and governor means for the future of the Affordable Care Act, Medicaid expansion, and managed care, and reports on important healthcare ballot measures from around the country.

Despite decades of efforts to target the Ras protein, mutated in a number of different cancers, the progress has been slow. Now, scientists at the Max Planck Institute of Molecular Physiology in Germany have devised a way to prevent translocation of Ras to the cell surface, a process essential for protein activation.

Healthcare reform initiatives may be on shaky ground after Republicans won important seats this midterm election, but health reform advocates are claiming victory in California after defeating an insurance rate initiative.

The study, published in JAMA, found a 50% improvement in survival in patients with metastatic melanoma who were treated with ipilimumab, if they simultaneously received an immune stimulant.

Large employer health plans will now be required to cover in-patient hospitalization services, according to a notice from the Treasury Department and HHS on Tuesday morning. The final regulation will be issued next year.

COTA will expand Foundation Medicine's molecular information knowledge base with longitudinal clinical outcomes and cost of care data and analytics.

Trebananib combined with paclitaxel improved survival by a month compared to the placebo, from 18.3 months to 19.3 months.

Using global budgets for healthcare instead of traditional fee-for-service improves quality of patient care and lowers costs, according to a new study by researchers from Harvard Medical School's Department of Health Care Policy.

According to Margaret Chan, the Director-General of the WHO, "A profit-driven industry does not invest in products for markets that cannot pay."

Their role is essential and growing as the nation's elderly population increases, and many older persons seek to stay in their homes. But with pay and benefits only a rung above fast food workers, home health aides are a little seen and often unheard part of the managed care continuum. That changed one September morning in Ohio, when a rally brought their plight literally into the sunshine.

The study by Andrew Mulcahy, a policy researcher at the RAND Corporation, found that the predicted $44 billion saving to the US healthcare system over the next decade, would depend on FDA decisions on newer biosimilar drug candidates.

The study, published in the Journal of the National Cancer Institute, found that out-of-pocket costs influenced adherence to hormone therapy in women with HR-positive, early-stage breast cancer.

Patient satisfaction may be increasingly important in healthcare, but the industry hasn't made the appropriate changes yet, 2 employees from Prime Therapeutics said in back-to-back sessions at the 64th Annual Roy A. Bowers Pharmaceutical Conference.

The BRCAnalysis test will be used in conjunction with Abbvie's novel PARP inhibitor veliparib for the treatment of breast cancer.

Research to be presented this week at the National Cancer Research Institute Cancer Conference has identified the expression of specific serum microRNAs in pediatric solid tumors, which could prove useful for early diagnosis.