Robert A. Gabbay, MD, PhD, FACP, chief medical officer at Joslin Diabetes Center, moderates a discussion on the role of combination therapy in several ways, including early aggressive therapy with combination treatment and the combination of taking 2 medications in 1 tablet to encourage adherence with increased convenience and reduced copays. He is joined by S. Sethu K. Reddy, MD, MBA, FRCPC, FACP, MACE; Ravi Retnakaran, MD, MSc, FRCPC; Alexander Turchin, MD, MS; and Helen Feit, MD.