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Scientists have found a possible link between maternal cholesterol levels and the risk of attention-deficit-hyperactivity disorder (ADHD) in children, with boys being more susceptible to the effect than girls.

Researchers have made a key discovery that could pave the way to designing an improved opioid to relieve pain without the risk of addiction and side effects.

Credit rater predicts Obamacare insurers will have a relatively stable 2018; Buffalo, New York, has the country's first opioid court aimed at saving lives; ambulance rides are down in cities with Uber.

Adolescent and young adults with attention-deficit/hyperactivity disorder (ADHD) are at a higher risk for subsequent sexually transmitted infections (STIs), but taking medicine for ADHD can help cut the risk, according to research published in the Journal of the American Academy of Child and Adolescent Psychiatry.

The US Chinese aging population has experienced a rapid growth in recent years. However, research about the social networks of older immigrant adults has been lacking. That scarcity of information has led to a lack of understanding that has limited the ability of US healthcare professionals and policy makers to provide the best strategies to improve the health and wellbeing of older Chinese adults.

Since the implementation of the Affordable Care Act (ACA), annual well visits among adolescents improved with visits increasing the most among Hispanic adolescents.

A federal judge dismissed a move to block 340B cuts days before CMS’ final rule on it went into effect.

Carfilzomib was associated with higher rates of all-grade and high-grade cardiovascular adverse events (CVAE), and both later trial phase and higher doses of carfilzomib were associated with higher rates of CVAE, according to a study in JAMA Oncology.

A study comparing costs and death rates for veterans obtaining percutaneous coronary intervention (PCI) found that when the procedure was performed at a community facility versus one operated by the Veterans Administration, the veteran was more likely to die and the procedure itself was more expensive. However, death rates were similar for elective coronary artery bypass grafts.

New vision loss gene therapy gets a price tag below the expected $1 million mark; new evidence finds that the prevalence of autism spectrum disorders has plateaued; hospitals are ill-equipped to care for dementia patients, but a new effort could change that.

A newer method for calculating low-density lipoprotein (LDL) cholesterol is more accurate than the older method that required people fast before blood was drawn.

New analyses focused on how health spending has changed over time, as well as the driving forces behind the spending growth.

Topical analgesics were safe and effective at reducing chronic pain, according to a study that also looked at whether or not a subgroup of patients were able to stop using opioids a few months after treatment. About 50% of patients were able to discontinue use of opioids after 3 or 6 months of treatment with pain-relieving analgesics applied directly to the skin, a study reported.

Patients with chronic obstructive pulmonary disease should be given the pneumococcal conjugate vaccine and influenza vaccines to decrease the risk of exacerbations. However, despite the evidence of vaccine efficacy, improvements are needed in coverage and awareness.

In a new study, published in Arthritis Research & Therapy, a research team led by Soo-Kyung Cho, MD, sought to investigate the incidence of malignancy in early rheumatoid arthritis and found that the use of biologic disease-modifying anti-rheumatic drugs decreased the overall risk of developing malignancies, though it did not affect the risk of developing hematologic malignancies.

A pre-treatment signature of proteins used to predict survival in patients with metastatic melanoma receiving PD-1 inhibitors found that patients deemed sensitive by the test demonstrated significantly better overall survival.

The Trump administration dismissed the remaining members of the Presidential Advisory Council on HIV/AIDS as it prepares to appoint members to the 2018 council.

FDA approved 46 drugs in 2017, a 21-year high; pilot program tests using home care to reduce emergency department visits; a look at how increasing prices, not increased use of services, has caused American healthcare spending to grow so much faster than peer nations.

New immuno-oncology agents are providing durable survival for some patients, but the cost of these treatments is very high, which is a cause for concern. In a new study in JAMA Oncology, researchers sought to assess how value frameworks defined the efficacy of new immuno-oncology agents.

To drive real innovation in Medicare Advantage—improvements that will result in better health outcomes and reduce costs—CMS should start with doctors.

A small pilot study from the Hollings Cancer Center at the Medical University of South Carolina found that smokers who are willing to use e-cigarettes tend to smoke less and have increased quit attempts.

Acute myeloid leukemia (AML) is the most common form of acute leukemia and has a poor 5-year survival rate, especially among older people. Cancer researchers have created a model that can predict mortality after AML treatment, so that it can help guide decision-making for patients and providers.

Management of pediatric oncology patients with febrile neutropenia and hospitalization duration currently vary by institution and by provider. A poster presented at the 59th American Society of Hematology Annual Meeting reviewed pediatric hematology/oncology patients who were admitted with febrile neutropenia to determine discharge and release, as well as subsequent readmission within the next 4 days.

Patients with cancer may have more options for oral cancer medications, but high out-of-pocket costs still present a barrier to access, according to a new study in Journal of Clinical Oncology.

This week, the top managed care stories included a road map to develop state-level programs to care for complex populations; the Physician-focused Payment Technical Advisory Committee backed 2 new alternative payment models; a new cancer gene profiling test may open doors to new targeted therapies.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Rhode Island and Vermont consider state-level individual insurance mandates; Utahns support full Medicaid expansion; CMS approves a first-of-its-kind 10-year Medicaid waiver for Mississippi.

A look at the most popular articles published in Evidence-Based Oncology™ in 2017.

Patients with atopic dermatitis (AD) have a significantly greater risk for additional atopic diseases, as well as significantly greater healthcare resource utilization and total cost compared with adults without AD. The burden of AD was generally comparable to that of psoriasis, although patients with AD reported increased use of emergency room visits compared with patients with psoriasis.

As 2017 came to close, The American Journal of Managed Care® (AJMC®) asked readers to weigh in on the events they believed had the greatest impact on managed care during the year. As the votes came in, it was clear that what happens in Washington, DC, matters—and that Capitol Hill policy makers will continue to make a difference in 2018.