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Data from a phase 2 study demonstrated that high-grade neuroendocrine carcinoma had a 42% overall response rate to the combination of nivolumab and ipilimumab.

The availability and affordability of healthcare is the most pressing concern of Americans, Gallup says in latest poll.

A new study in Health Affairs comes within a week of a federal ruling that found Medicaid work requirements in Arkansas and Kentucky failed to meet requirements of the 1965 law creating the program.

A recent literature review assessed the efficacy of beta-blockers to prevent migraine and tension headache. It found that propranolol worked better than placebo for episodic migraine headaches, but the evidence for efficacy in tension headaches was limited.

By providing case management, self-management education, and skills training, integrated disease management is associated with fewer exacerbations and improved quality of life (QOL) among patients with chronic obstructive pulmonary disease (COPD) enagaged in primary care.

CMS approves Utah Medicaid work requirements after a federal judge overturns rules for Arkansas and Kentucky; youth suicide risk in Missouri grows with the shift to managed care; CDC says a goal of eliminating tuberculosis by end of 21st century unlikely.

As novel therapies drive up the cost of drugs, it is becoming increasingly difficult for community oncologists to keep costs below value-based care program targets, according to a new survey from Integra Connect.

A recent study found that aerobic exercise may be associated with a reduced number of migraine days in patients who experience migraine.

Researchers from South Korea said they have developed a next-generation sequencing (NGS) assay to detect somatic mutations, translocations, and germline mutations in a single assay for the purpose of supplementing or replacing conventional tests in patients with myeloid neoplasms.

A comprehensive genomic analysis of acute erythoid leukemia (AEL) found that 45% of patients had mutations in signaling pathways that drive uncontrolled cell growth, and evidence shows these leukemias may respond to existing precision treatments.

The revolution in cancer care isn’t just about the wave of life-saving therapies, or the role of genetics in pinpointing exactly who should get which drug and when. As Ray D. Page, DO, PhD, FACOI, tells it, change also means getting back to the basics, so that the relationship between doctor and patient drives care—not insurance companies or Medicare or rules from the FDA.

A study consisting of interviews and focus groups among patients with relapsed or refractory multiple myeloma brought attention to what patients value about their treatment.

During the Academy of Managed Care Pharmacy (AMCP) Managed Care & Specialty Pharmcy Annual Meeting, held March 25-28, in San Diego, California, managed care professionals from across the globe gathered to discuss opportunities and challenges facing stakeholders in pharmaceutical management, ranging from drug pricing reform to strategies to address the opioid epidemic.

Recent work looking at the response to immune checkpoint blockade (ICB) therapy given before surgery for advanced melanoma found increased infiltration of B cells, a type of white blood cell, in patients who responded to therapy compared with those who did not.

This week, the top managed care news included the Department of Justice siding with a federal judge in striking down the Affordable Care Act; FDA Commissioner Scott Gottlieb, MD, calling for stricter oversight of electronic health records; and a study finding that healthy eating in Medicare and Medicaid is cost effective.

Another federal district court judge has handed the Trump administration a major defeat this week in its attempts to redo rules about US health insurance, saying that its efforts to expand association health plans (AHPs) were “clearly an end-run” around the Affordable Care Act (ACA).

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

An Idaho Senate committee killed a bill that would implement Medicaid work requirements in the state; the FDA is proposing requiring that women receive information on their breast density after a mammogram; and President Trump will reportedly submit a healthcare plan to Congress this year.

This week, drug maker Celgene resubmitted its New Drug Application (NDA) to the FDA for RPC-1063 (Ozanimod), seeking an indication for the treatment of adults with relapsing multiple sclerosis.

If used properly, artificial intelligence will restore the human connection between doctors and patients, says Eric Topol, MD.

Insurer Centene strikes a deal to acquire WellCare, creating a new giant in the healthcare market; a federal jury orders Monsanto to pay over $80 million to a plaintiff whose cancer was found to be caused by a common weed killer; surgeons perform a transplant using a kidney from a living donor with HIV.

A presentation of a meta-analysis at ENDO 2019 said losing weight can help improve migraines.

Electronic medical record data on patients with multiple sclerosis is generally consistent with research data and can be used to expand research opportunities, according to a new study.

A US District Court judge in Washington, DC, agreed with plaintiffs who argued that the HHS Secretary did not act reasonably in allowing states to create work requirements for beneficiaries to receive healthcare. Orders sending both state waivers back to HHS are expected today.

In an ongoing study, researchers seek to determine whether a staggered, "step up" intervention model could be more successful and cost-effective than standard care for achieving viral suppression in youths living with HIV.

Louisiana's Departments of Health and Corrections announced this week their selection of Asegua Therapeutics, a generics subsidiary arm of Gilead Sciences, as their pharmaceutical partner for the state’s “Netflix” subscription model for hepatitis C virus (HCV) treatment. Asegua won the deal over Merck and AbbVie, which each submitted bids for the subscription model.

A lack of diversity in cell lines used for laboratory studies means underrepresented populations and minorities might not benefit from precision medicines as quickly as people from European ancestry.

HHS Secretary Alex Azar and Attorney General Bill Barr opposed the Trump administration’s support to overturn the Affordable Care Act (ACA) through a federal lawsuit; OxyContin maker Purdue Pharma and its owners, the Sackler family, agreed to pay $270 million to avoid a state court trial in Oklahoma over the company’s role in the spread of opioids over the past 20 years; a New York county is banning unvaccinated children in public places in the wake of a measles crisis that has infected more than 150 people.

Individuals with an obstructive lung disease saw improvement in lung function when they replaced 30 minutes of sedentary time per day with strenuous or strength-building physical activity.