Oncology

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NSCLC | Image: Lung Cancer Foundation of America

Zongertinib Shows Durable Responses With No Interstitial Lung Disease in HER2-Mutated Advanced NSCLC

By Mary Caffrey
Brooke McCormick

April 28th 2025

Results could give patients with HER2-mutated non–small cell lung cancer (NSCLC) an oral therapy option.

Considering the life-threatening risk of TLS, the researchers underscored the importance of identifying patients at particular risk of the complication. | Image credit: mi_viri - stock.adobe.com

Optimized Strategies Needed for TLS Prevention, Intervention in SCLC

By AJMC Contributor

April 23rd 2025

Diabetes monitoring | Image credit: abidika - stock.adobe.com

New-Onset Type 2 Diabetes Linked to Higher Cancer Risk

By Pearl Steinzor

April 23rd 2025

Vitamin D | Image credit: Galina Zhigalova - stock.adobe.com

Vitamin D’s Potential Role in Colorectal Cancer Prevention, Immune Health

By Pearl Steinzor

April 23rd 2025

The study highlighted symptom patterns in the short-term preceding ED visits and unplanned hospitalizations using a previously validated natural language processing a pipeline. | Image credit: Tyler Olson - stock.adobe.com

Symptom Documentation Differences in Acute Cancer Care Suggest Sociodemographic Disparities

By Rose McNulty

April 22nd 2025

Join this expert panel to discuss precision medicine in NSCLC, current immunotherapies, and more.

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Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations

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February 19th 2018

Cancer Survivors Manage Fatigue With Placebo Pills

Kaitlynn Ely

Cancer survivors may be able to manage the extreme fatigue they experience after treatment by knowingly taking a placebo pill, according to researchers at University of Alabama at Birmingham and Harvard Medical School.

February 18th 2018

USPSTF Recommends Against Screening for Ovarian Cancer in Asymptomatic Women

Jaime Rosenberg

The US Preventive Services Task Force recommends against screening for ovarian cancer in asymptomatic women who are not known to have a high-risk hereditary cancer syndrome because evidence shows that screening does not reduce ovarian cancer mortality.

February 17th 2018

Variation in Markups on Outpatient Oncology Services in the United States

Angela Park Tim Xu, MD, MPP Michael Poku, MD, MBA James Taylor, MBBChir, MPH, MRCS(Eng) Martin A. Makary, MD, MPH

Charges for oncology services vary widely across hospitals and impose financial burdens. Further legislation is needed to address disparities in access to high-quality cancer care.

February 17th 2018

Study Finds Merkel Cell Carcinoma Incidence Has Increased Since 2000

Kaitlynn Ely

Merkel cell carcinoma (MCC) is a rare disease, but it's getting less rare. Study results presented at the American Academy of Dermatology 2018 Annual Meeting found that cases of MCC increased 95% between 2000 and 2013

February 17th 2018

eAppendix

Dave Nellesen, PhD Katerine Dea, MSc Annie Guerin, MSc Kenneth W. Culver, MD Alex Mutebi, PhD Anand Dalal, MBA, BSPharm

February 16th 2018

Development of a Tailored Survey to Evaluate a Patient-Centered Initiative

Marcy Winget, PhD Farnoosh Haji-Sheikhi, MS Steve M. Asch, MD, MPH

We developed short patient experience surveys that were sensitive to our broad quality initiative, were meaningful and acceptable to patients, and had good response rates.

February 16th 2018

AJMC® in the Press, February 16, 2018

AJMC Staff

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

February 16th 2018

Roche Acquires Flatiron Health for $1.9 Billion

Mary Caffrey

Flatiron Health expects to maintain its current business model in the transaction.

February 16th 2018

Nat Turner on the Main Barriers for Flatiron Health in Providing Care in Oncology

Nat Turner, co-founder and CEO of Flatiron Health, says that clinical research accessibility is one of the biggest barriers in oncology care that Flatiron Health is working to remove.

February 15th 2018

Pricing of Monoclonal Antibody Therapies: Higher If Used for Cancer?

Inmaculada Hernandez, PharmD, PhD Samuel W. Bott, BS Anish S. Patel, BS Collin G. Wolf, BS Alexa R. Hospodar, BS Shivani Sampathkumar, BS William H. Shrank, MD, MSHS

The annual price of monoclonal antibody therapies used in oncology and hematology is about $100,000 higher than those used in other disease states.

February 15th 2018

Family History Associated With Breast Cancer Risk for Women 65 and Older

Jaime Rosenberg

First-degree family history was associated with an increased risk of breast cancer among women aged 65 and older, and risk associated with family history was not significantly modified by breast density, according to a study in JAMA Oncology.

February 15th 2018

FDA Approves Apalutamide, First Treatment for Nonmetastatic Castration-Resistant Prostate Cancer

Laura Joszt, MA

FDA has approved apalutamide, the first treatment for nonmetastatic castration-resistant prostate cancer, based on results from a phase 3 study that showed the drug reduced the risk of metastasis or death by 72% and improved median metastasis-free survival by more than 2 years.

February 15th 2018

ASCO and NCCN Release Guidelines on Managing Immunotherapy-Related Toxicities

Kelly Davio

The American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network (NCCN) have developed new guidelines on managing immune checkpoint inhibitor-related toxicities.

February 14th 2018

Pembrolizumab Associated With Increased Overall Survival in Patients With Urothelial Cancer

Jaime Rosenberg

There is a greater overall survival benefit for patients with recurrent urothelial cancer being treated with pembrolizumab versus chemotherapy, according to long-term results of the KEYNOTE-045 trial.

February 13th 2018

ASCO Review Finds Clinical Pathway Programs Adhere to Guidelines

Samantha DiGrande

Last week, the American Society of Clinical Oncology (ASCO) published its review of the leading oncology pathway vendors in the United States in the Journal of Oncology Practice. The report found that overall, the prominent commercial pathway programs in the United States are aligned with ASCO’s evaluation criteria.

February 13th 2018

Kentucky's Medicaid Expansion Associated With Improved Breast Cancer Care

Jaime Rosenberg

Medicaid expansion in Kentucky led to an increase of screening mammograms, screening coverage, and breast-conserving surgery for women aged 20 to 64 with breast cancer, according to a study published in the Journal of the American College of Surgeons. However, the study also showed that time from diagnosis to operation increased post expansion and time from operation to chemotherapy remained unchanged.

February 12th 2018

Dr Roger Brito Discusses Practitioners Taking on 2-Sided Risk

We want to know all sides of the 2-risk model, like with any challenge or strategy, said Roger Brito, DO, national director for oncology, Aetna.

February 11th 2018

Dr Sumit Subudhi Discusses Immune Checkpoint Inhibitors in Prostate Cancer

In prostate cancer, we're using combinations by looking to see how 1 drug may trigger an immune infiltrate or proteins that allow the tumor to resist the monotherapy, said Sumit Subudhi, MD, PhD, genitourinary medical oncology, MD Anderson Cancer Center.

February 10th 2018

Podcast: This Week in Managed Care—Cancer Survival Rates and Other Health News

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

February 10th 2018

Docetaxel Plus Hormone Therapy Improved QoL, Cost Effectiveness in Prostate Cancer

Jaime Rosenberg

The addition of docetaxel to first-line long-term hormone therapy in patients with prostate cancer is associated with improved quality of life (QoL) benefits and cost effectiveness, according to study results presented at the 2018 Genitourinary Cancers Symposium.

February 10th 2018

Medicaid Expansion Led to Earlier Stage at Diagnosis of Testicular Cancer

Jaime Rosenberg

There was a reduced rate of uninsured patients at the time of diagnosis and a shift to earlier stage at time of diagnosis for patients with testicular cancer in states that adopted Medicaid expansion in 2014, according to findings presented at the 2018 Genitourinary Cancers Symposium.

February 10th 2018

Daily IGRT in Prostate Cancer Reduces Risk of Recurrence, Increases Risk of Second Cancer

Jaime Rosenberg

Daily image-guided radiotherapy, when compared to weekly control, decreases the risk of recurrence and rectal toxicity, but is associated with an increased risk of second cancer, according to study results presented at the 2018 Genitourinary Cancers Symposium.

February 10th 2018

Dr Christopher Kane on Robotic Procedures in Prostate Cancer

Robotic procedures have really exploded in prostate cancer, said Christopher Kane, MD, professor of urology, University of California, San Diego. Robotic radical prostatectomy is now the most common way a radical prostatectomy is done in the United States.

February 10th 2018

Eligibility Requirements Exclude Black Patients From Prostate Cancer Clinical Trials

Kaitlynn Ely

Black patients with prostate cancer are underrepresented in clinical trials due to eligibility requirements that exclude patients with benign ethnic neutropenia, according to a new study published in JAMA Oncology.

February 10th 2018

Use of Biomarkers to Identify Patients, Therapies for Neoadjuvant Chemotherapy

Jaime Rosenberg

During a session at the 2018 Genitourinary Cancers Symposium, Peter Black, MD, professor, department of urologic sciences, University of British Columbia, discussed using molecular subtypes, the Coxen model, and gene mutations to select patients and therapies for neoadjuvant chemotherapy.

February 10th 2018

Combining Radiation and Immunotherapy in Patients With Bladder Cancer

Jaime Rosenberg

During a session at the 2018 Genitourinay Cancers Symposium, Abhishek Solanki, MD, MS, assistant professor, radiation oncology, Loyola University of Chicago discussed the role of immunotherapy in patients undergoing radiation therapy for bladder cancer.

February 10th 2018

Guidelines for Management of Muscle-Invasive Bladder Cancer

Jaime Rosenberg

With new guidelines on how to treat and manage muscle-invasive bladder cancer, Jeffrey Holzbeierlein, MD, FACS, professor of urology, director of urologic oncology, interim chair of the department of urology, University of Kansas Health System, provided insight into how the guidelines have changed the management of the disease at the 2018 Genitourinary Cancers Symposium.

February 9th 2018

This Week in Managed Care: February 9, 2018

This week, the top managed care stories included Indiana being approved as the second state to implement work requirements in Medicaid; research found 5-year survival rates for cancer are increasing; coverage from the American Society of Clinical Oncology's 2018 Genitourinary Symposium.

February 9th 2018

Is There Evidence for Local Treatment for Newly Diagnosed Metastatic Prostate Cancer?

Jaime Rosenberg

During a session at the 2018 Genitourinary Cancers Symposium, 2 doctors debate whether there is existing evidence for local treatment for patients newly diagnosed with metastatic disease.

February 9th 2018

Dr Joe O'Sullivan on Molecular Therapies in Prostate Cancer

For the first time, molecular therapies, such as radium-223, provide a survival-prolonging agent for men with advanced prostate cancer affecting the bone, explained Joe O'Sullivan, MD, FRCR, clinical professor, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast.

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