Leukemia and Lymphoma

The AJMC^® Leukemia & Lymphoma compendium is a comprehensive resource for clinical news and expert insights for the blood cancers and their treatments.

Latest News

June 18th 2024

BrECADD Regimen Reaches “Unprecedently High” PFS for Patients With Hodgkin Lymphoma

By Laura Joszt, MA

March 7th 2024

Zanubrutinib Plus Obinutuzumab Granted Accelerated FDA Approval for R/R Follicular Lymphoma

By Rose McNulty

December 22nd 2023

alloHSCT Yields Benefits in R/R AML Regardless of Leukemia Burden

By Russ Conroy

December 20th 2023

ICYMI: Highlights From ASH 2023

By Rose McNulty

December 11th 2023

Zanubrutinib May Be Viable Option After Acalabrutinib Intolerance in B-Cell Malignancies

By Conor Killmurray

Video Interviews

November 21st 2023

New Therapeutic Approaches Are Needed to Improve High-Risk MCL Outcomes: Dr Amitkumar Mehta

October 15th 2023

Dr Alma Habib: Effort Needs to Be Put Into Addressing Disparities in Leukemia, Lymphoma Care

October 12th 2023

Dr Jennifer Vaughn: Value-Based Care Concerns Cost and Patient Experience

October 10th 2023

Dr Sarah Wall: Putting Attention on Older Adults With Blood-Based Cancer Is Vital Moving Forward

October 2nd 2023

Dr Adam Kittai Emphasizes 2 Crucial Reasons Value-Based Care Is Important for Blood-Based Cancers

July 25th 2023

Patients With CML Feel Shared Decision-Making Is Lacking, Want More Focus on QOL

July 20th 2023

Dr Wojciech Jurczak Discusses Changing Treatment Options for R/R DLBCL

July 11th 2023

Dr Fabian Lang Discusses Provider-Patient Communication in CML

July 7th 2023

Dr Fabian Lang on the Importance of Patient Involvement in CML Treatment Decisions

June 16th 2023

Dr Tycel Phillips on the Need for Novel Therapies for DLBCL

Podcasts

February 3rd 2022

Lymphoma Research Foundation CEO on Biden’s Cancer Moonshot, Financial Toxicity

October 13th 2021

Keeping Patients With Cancer Out of the ED Through Dedicated Urgent Care

August 4th 2019

Podcast: This Week in Managed Care—Drug Importation Plan and Other Health News

Continuing Medical Education

November 19th 2024

ASH Annual Meeting Coverage: Highlighting the Recent Updates in TKI Use in the Treatment of CML – Insights and Application for Managed Care

December 18, 2024 | 1:00 PM & 8:00 PM ET

November 19th 2024

Keeping Pace With New Developments in Multiple Myeloma: Updates and Strategies to Optimize Bispecific Antibodies and CAR T-Cell Therapy

1.5 Credits / Oncology, Hematology, Hematologic Cancer

November 19th 2024

Addressing the Gaps and Clinical Challenges in Chronic Lymphocytic Leukemia: Updates and Strategies for Managed Care

1.5 Credits / Hematology, Hematologic Cancer, Oncology

More News

Blood cells flowing | Image credit: Катерина Євтехова - stock.adobe.com

December 8th 2023

Health Care Resource Use, Cost Burden Appear Substantial in R/R B-Cell ALL

Treatment with blinatumomab or inotuzumab ozogamicin particularly confers higher total costs for patients with relapsed/refractory B-cell acute lymphoblastic leukemia.

FDA Investigating Reports of T-Cell Malignancies Following CAR T-Cell Therapy

November 28th 2023

FDA Investigating Reports of T-Cell Malignancies Following CAR T-Cell Therapy

The announcement applies to all currently approved therapies, both BCMA-directed and CD19-directed genetically modified autologous chimeric antigen receptor (CAR) T-cell treatments.

Blood Cells | Image credit: Катерина Євтехова - stock.adobe.com.jpg

November 25th 2023

Evolving Treatment Patterns Lead to Improved Outcomes in Relapsed/Refractory MCL

Patients with relapsed/refractory mantle cell lymphoma have experienced event-free survival and overall survival benefits due to advances in second-line treatment approaches over time.

Image credit: LASZLO | stock.adobe.com

November 18th 2023

Base-Edited T Cells Could Minimize Immunotherapy Complications in Leukemia, Study Suggests

The use of base editing to generate universal, off-the-shelf CAR T cells is a promising approach for relapsed leukemia, with potential implications for the future of gene therapy.

CAR T cell AI-generated image | Image credit: AIGen - stock.adobe.com

November 17th 2023

Review Explores Link Between Tumor Burden, CAR T-Cell Therapy Efficacy

A recent review aimed to characterize the relationship between tumor burden and clinical outcomes in patients treated with chimeric antigen receptor (CAR) T-cell therapy, highlighting the potential mechanisms of high tumor burden impacting CAR T-cell failure.

Child laying in hospital bed | Image credit: wavebreak3 - stock.adobe.com.jpg

November 3rd 2023

High Disease Burden at Acute Leukemia Diagnosis More Common in Black Children, Study Finds

A study evaluating disparities among children with acute leukemia found that Black children are more likely to present with higher disease burden at diagnosis compared with non-Hispanic White children.

FDA Approved | Image credit: chrisdorney - stock.adobe.com

October 27th 2023

FDA Approves Bosutinib for Pediatric Patients With CP-CML

Bosutinib has a new indication in leukemia as a well as a newly-approved formulation.

Mantle cell lymphoma Image credit: David A Litman - stock.adobe.com

October 23rd 2023

Zanubrutinib Associated With Better OS in Second vs Later Lines of R/R MCL Therapy

A pooled analysis with nearly 3 years of follow-up showed better outcomes when zanubrutinib was given in the second line vs later lines of therapy in patients with relapsed or refractory (R/R) mantle cell lymphoma (MCL).

High LDH Levels Associated With Worse Survival in Newly Diagnosed AML

October 13th 2023

High LDH Levels Associated With Worse Survival in Newly Diagnosed AML

Elevated white blood cell counts also appear to correlate with shorter overall survival in patients receiving standard induction chemotherapy plus cytarabine for acute myeloid leukemia.

Lymphoma | Image credit: Dr_Microbe - stock.adobe.com

October 6th 2023

Bridging RT Before CAR T-Cell Therapy Can Benefit Patients With R/R DLBCL

Researchers found that patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) may benefit from bridging radiation therapy (RT) ahead of receiving chimeric antigen receptor (CAR) T-cell therapy.

FDA Approved | Image credit: chrisdorney - stock.adobe.com

September 28th 2023

FDA Approves Bosutinib for Pediatric Chronic Myelogenous Leukemia

Based on findings from the phase 1/2 BCHILD trial, the FDA approved bosutinib for pediatric chronic myelogenous leukemia.

DNA | Image credit: vitstudio - stock.adobe.com

September 22nd 2023

DNA Index Most Effectively Identifies Patients With Hyperdiploid ALL

The measure of total DNA in leukemic cells as defined by a DNA index outperformed other criteria for identifying patients with hyperdiploid acute lymphoblastic leukemia (ALL) and favorable prognosis.

Woman comforting another woman with cancer | Image credit: Photographee.eu - stock.adobe.com

September 21st 2023

Support and Follow-Up Are Needed to Combat Distress in Lymphoma

Several discrepancies in care must be considered to properly address psychological needs in patients with lymphoma, including patient/doctor communication, information provision, and applying distress guidelines.

FDA approval stamp | Image credit: Olivier Le Moal - stock.adobe.com

September 15th 2023

FDA Approves Momelotinib for Myelofibrosis With Anemia

The agency's approval of momelotinib marks the first for both newly diagnosed and previously treated myelofibrosis with anemia.

Leukemia cell | Image credit: Dr_Microbe - stock.adobe.com

September 9th 2023

Ponatinib Plus Chemotherapy Elicits MRD-Negative Remissions in Certain Patients With ALL

Ponatinib also produces an improvement in progression-free survival compared with imatinib among those with Philadelphia chromosome-positive acute lymphoblastic leukemia in the phase 3 PhALLCON trial.

Blood cells | Image credit: flashmovie - stock.adobe.com

September 8th 2023

AML-Specific Early Mortality Risk Indices May Increase Accuracy of Care Quality Measurements

A study found acute myeloid leukemia (AML) salvage therapy was independently associated with early mortality compared with frontline therapy, suggesting that algorithms measuring quality of care should incorporate risk mortality indices that factor in disease characteristics and treatment status.

Heart and stethescope

August 30th 2023

Cardiac Radiotherapy May Increase Late Disease Risk in Pediatric Cancer Survivors

Nicholas Wrigley

Increasing radiation doses to the whole heart appear to correlate with higher risks of valvular disease, coronary artery disease, and heart failure in childhood cancer survivors, a recent study found.

image of leukemia cell

August 29th 2023

Older Patients With AML Less Likely to Receive Genomic Testing, Study Finds

A study highlights an unmet need for patients with acute myeloid leukemia (AML) to access and afford genomic testing, especially among an older patient population.

Lymphoma cell

August 18th 2023

CAR T-Cell Therapy Shown Safe, Effective in MCL With CNS Involvement

A small study suggests the use of anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in patients with mantle cell lymphoma (MCL) with secondary central nervous system (CNS) involvement is safe and effective.

CAR T cells

August 12th 2023

Receiving More Therapies Prior to CAR T-Cell Therapy May Worsen Outcomes in NHL

Nicholas Wrigley

Findings from a retrospective analysis suggest an association between bridging therapy and poorer outcomes among patients with aggressive, relapsed/refractory B-cell non-Hodgkin lymphoma (NHL).

Heart Health Image

August 10th 2023

Atorvastatin May Mitigate Risk of Cardiac Events Due to Anthracycline Use in Lymphoma

Anthracyclines are widely used to treat hematological and solid-tumor cancers, but past research suggests their use may be associated with late cardiac effects, including heart failure, among patients with lymphomas and other cancers.

July 31st 2023

ASCO 2023: Leukemia and Lymphoma

Mary Caffrey Rose McNulty Jordyn Sava

Results include a landmark study that involved seamless collaboration across adult and pediatric patient groups, leading to a highly diverse study population. Other coverage addresses access to novel therapies and what's coming in the pipeline, including CAR T-cell therapy with tyrosine kinase inhibitors.

Higher Spleen Volume at HSCT Associated With Worse Outcomes in AML

July 21st 2023

Higher Spleen Volume at HSCT Associated With Worse Outcomes in AML

A recent study found that higher spleen volume before undergoing allogeneic hematopoietic stem cell transplantation (HSCT) was associated with worse overall survival and higher nonrelapse mortality incidence in patients with acute myeloid leukemia (AML).

FDA Accepts sNDA for Zanubrutinib Plus Obinutuzumab for R/R Follicular Lymphoma

July 12th 2023

FDA Accepts sNDA for Zanubrutinib Plus Obinutuzumab for R/R Follicular Lymphoma

Following positive phase 2 results from the ROSEWOOD study, BeiGene is seeking FDA approval of zanubrutinib plus obinutuzumab for select patients with relapsed/refractory (R/R) follicular lymphoma.

Lab assistant, a medical scientist, a chemistry researcher holds a glass tube through the blood sample, does a chemical experiment and examines a patient's blood sample. Medicine and research concept: © PhotosD - stock.adobe.com

July 2nd 2023

Review Highlights Use of MRD in AML, ALL, CML

Measurable residual disease (MRD) can predict disease progression in patients who have acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL) and chronic myeloid leukemia (CML).

acute lymphoblastic leukemia blasts

June 28th 2023

Looking Ahead at CAR T-Cell Therapy for R/R Acute Lymphoblastic Leukemia

Presentations on the first day of the 2023 American Society of Clinical Oncology Annual Meeting covered data on a split dose CAR T-cell therapy and a CAR T therapy manufactured with TKI.

Genetically engineered chimeric antigen receptor immune cell with implanted gene strain - 3d illustration: © Christoph Burgstedt - stock.adobe.com

June 27th 2023

Real-World Evidence Shows CAR T-Cell Therapy Effective in Older Patients With Relapsed/Refractory DLBCL

Jared Kaltwasser

The therapy is still not widely used among older patients who have diffuse large B-cell lymphoma (DLBCL).

Study Explores Real-World BTK Inhibitor Use Patterns in Mantle Cell Lymphoma

June 24th 2023

Study Explores Real-World BTK Inhibitor Use Patterns in Mantle Cell Lymphoma

The study was conducted to provide insight into real-world Bruton tyrosine kinase (BTK) inhibitor treatment patterns in mantle cell lymphoma, as current data are limited.

Earlier Use of CAR T Cells Holds Promise in Blood Cancers, but Access Remains an Issue

June 23rd 2023

Earlier Use of CAR T Cells Holds Promise in Blood Cancers, but Access Remains an Issue

A panel of experts at the American Society of Clinical Oncology Annual Meeting presented the latest research and equity considerations for chimeric antigen receptor (CAR) T-cell therapy in hematological cancers.

red FDA approved stamp

June 16th 2023

FDA Approves Glofitamab-gxbm to Treat Adults With Relapsed/Refractory DLBCL

Laura Joszt, MA

Glofitamab is the first bispecific antibody with a fixed-duration treatment for adults with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).

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