Hematology

Latest News

Elevating Value in Cancer Care With Innovations, Accessibility, Equity

By Cameron Santoro

November 21st 2024

Coverage from the IVBM Regional event in Denver, Colorado.

AML cells concept | image credit: sovova - stock.adobe.com

Study Reveals Leukemia Transplant Successes and Persistent Relapse Risks

By Kimberly Rath, PharmD

November 21st 2024

Multiple Myeloma | Image Credit: © Dzmitry-stock.adobe.com

OS Better With Belantamab Mafodotin Triplet vs Daratumumab in R/R MM

By Jordyn Sava

November 19th 2024

Don M. Benson, MD, PhD, James Cancer Hospital

Elevating Myeloma Care Amidst Complex Treatment Choices

By Maggie L. Shaw

November 15th 2024

NUP98 Rearrangements Linked to Poor Outcomes in AML

By Kimberly Rath, PharmD

November 15th 2024

More News

June 13th 2019

Survival of Patients With Multiple Myeloma Has Continued to Improve

Wallace Stephens

Survival of patients with multiple myeloma has continued to improve as treatments have evolved over time.

June 8th 2019

Multimorbidity, Insurance Status May Affect Survival Rates of Patients With Multiple Myeloma

Wallace Stephens

According to 2 abstracts presented at the 2019 American Society of Clinical Oncology Annual Meeting, multimorbidity, insurance status, and income may affect survival rates of patients with multiple myeloma.

June 7th 2019

5 Takeaways From ASCO's Annual Meeting

Samantha DiGrande

The American Society of Clinical Oncology recently held its annual meeting in Chicago, Illinois. The meeting brought together oncologists, payers, and other stakeholders to discuss the latest updates and therapeutic advances in cancer care. Here are 5 of the biggest takeaways from the meeting.

May 31st 2019

Adding Daratumumab to Standard Treatment Lowered the Risk of Death, Disease Progression in Patients With Multiple Myeloma

Wallace Stephens

The addition of daratumumab to standard treatment of lenalidomide and dexamethasone for patients with multiple myeloma, who were ineligible for autologous stem-cell transplant, was found to significantly lower the risk of disease progression or death compared with those who only received standard treatment.

May 31st 2019

Patients With Prior Hematologic Malignancy at Increased Risk for Head and Neck Cancer, Study Finds

Samantha DiGrande

According to results from a recent retrospective study, patients previously diagnosed with a hematologic malignancy were found to be at a higher risk of developing head and neck cancers compared with patients without a prior hematologic malignancy.

May 25th 2019

Is Sickle Cell Trait Associated With Cognitive Impairment in African Americans?

Wallace Stephens

Analysis of findings from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study found no association between sickle cell trait and cognitive impairment.

May 23rd 2019

Lenalidomide Beats Standard of Care in Smoldering MM

Samantha DiGrande

As a precursor to myeloma, smoldering multiple myeloma (MM) currently has no treatment. In fact, the standard of care is observation until the patient starts to present with symptoms. However, according to new research that will be presented at the American Society of Clinical Oncology’s annual meeting in Chicago, Illinois, held May 31 to June 4, early treatment of smoldering MM may delay progression to full-blown disease.

May 16th 2019

Venetoclax Gains FDA Approval for Previously Untreated CLL, SLL

Jaime Rosenberg

Venetoclax (Venclexta) has received FDA approval in combination with obinutuzumab (Gazyva) for the treatment of adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), offering a chemotherapy-free regimen for patients with previously untreated disease.

May 16th 2019

Finding the Trigger That Sets Off Growth of Hodgkin Lymphoma Cells

Mary Caffrey

Cure rates for Hodgkin lymphoma are high, but survivors may live for decades with side effects from chemotherapy. Finding a new treatment target could lead to fewer toxic effects.

May 11th 2019

Study Identifies New Therapy Target For Blood Cancers in Mitochondria of Cancer Cells

Jaime Rosenberg

Researchers have identified a new target in the mitochondria of cancer cells that indicate the potential of a treatment class for certain blood cancers.

May 10th 2019

Triple-Therapy Combo Without Chemo to Be Studied in DLBCL

Mary Caffrey

Proof-of-concept studies suggest the treatment that targets CD47 produces a strong response in patients with diffuse large B-cell lymphoma (DLBCL) with fewer adverse effects than current options.

May 2nd 2019

IgL Translocation May Predict Poor Outcomes in Multiple Myeloma

Jaime Rosenberg

DNA rearrangement may be the key to predicting poor outcomes in high-risk patients with multiple myeloma, according to a new study.

May 2nd 2019

Chemo, Then Radiotherapy, May Boost Survival for Patients With Advanced Hodgkin Lymphoma

Mary Caffrey

Radiotherapy after chemotherapy is controversial, as evidenced by the fact that doctors for some patients in the study did not follow the protocol for those assigned to radiotherapy and may have affected the results.

April 25th 2019

A Slower, Gentler CAR T-Cell Therapy? USC Says a Small Study Shows It Could Work

Mary Caffrey

Modifications to the engineering of the chimeric antigen receptor (CAR) mean that the patient produces fewer cytokines and has time to clear them before they build up in the bloodstream.

April 24th 2019

CMS Proposes Increased Reimbursement for CAR T-Cell Therapy, Price Hikes for Rural Hospitals

Jaime Rosenberg

As part of CMS’ FY 2020 Medicare Hospital Inpatient Prospective Payment System and Long-Term Acute Care Hospital Prospective Payment System Proposed Rule and Request for Information, the agency is proposing an increase in how much it reimburses hospitals for chimeric antigen receptor (CAR) T-cell therapy, as well as wage index hikes for rural hospitals.

April 16th 2019

Foundation Launches Investment Fund to Speed Multiple Myeloma Treatments

AJMC Staff

The investment fund spun off from the Multiple Myeloma Research Foundation will start at $50 million and will be self-sustaining, focusing on early-stage biotech companies.

April 16th 2019

Peripheral Neuropathy Significantly Adds to Cost Burden of Multiple Myeloma

Jaime Rosenberg

Among patients with multiple myeloma treated with older proteasome inhibitors, those who developed peripheral neuropathy (PN) had significantly higher costs, suggesting that newer therapies may maintain effective treatment while lowering the economic and disease burden of PN in these patients.

April 13th 2019

Experimental Cancer Vaccine Shrinks Tumors in Form of Non-Hodgkin Lymphoma

Mary Caffrey

A preliminary study discussed how a vaccine regimen stimulated dendritic cells to attack tumors, which could point to a new way of making immunotherapy effective in cancers that have proved resistant to treatment thus far.

April 11th 2019

Carfilzomib Regimen Safe, Effective in Newly Diagnosed, Transplant-Eligible Multiple Myeloma

Jaime Rosenberg

Assessing 4 dose levels of carfilzomib, researchers have determined that the drug, in combination with thalidomide and low-dose dexamethasone, is highly safe and effective in transplant-eligible patients with newly diagnosed multiple myeloma.

April 6th 2019

Step Therapy in Medicare Advantage Hurts Patients, Providers, Says Schwartzberg

Mary Caffrey

Step therapy, which requires that patients try the payer’s preferred treatment before the one a physician recommends, is harmful to both sides of the doctor-patient relationship, according to Lee B. Schwartzberg, MD, medical director of the West Cancer and Research Institute, who spoke at the 2019 Community Oncology Conference, held in Orlando, Florida.

April 6th 2019

Study Identifies High Rates of Adherence to IMIDs Among Patients With Multiple Myeloma

Jaime Rosenberg

A study of patients with multiple myeloma in a real-world setting found that adherence to immunomodulatory drugs (IMIDs) is high across all 3 options of the drugs.

March 30th 2019

Genomic Analysis of High-Risk Leukemia Finds Nearly Half of Cases May Respond to Precision Therapy

Mary Caffrey

A comprehensive genomic analysis of acute erythoid leukemia (AEL) found that 45% of patients had mutations in signaling pathways that drive uncontrolled cell growth, and evidence shows these leukemias may respond to existing precision treatments.

$Patient Preferences Should Be Considered for Treatment of Relapsed or Refractory Multiple Myeloma$

March 30th 2019

Patient Preferences Should Be Considered for Treatment of Relapsed or Refractory Multiple Myeloma

Jaime Rosenberg

A study consisting of interviews and focus groups among patients with relapsed or refractory multiple myeloma brought attention to what patients value about their treatment.

March 22nd 2019

FDA Stops Enrollment in Phase 3 MM Trial Due to 2-Fold Increase in Mortality

Samantha DiGrande

This week, the FDA sent out an alert to various healthcare professionals and the public to warn about the risks associated with the investigational use of venetoclax (Venclexta) for the treatment of patients with multiple myeloma (MM). The alert is based on data from the ongoing phase 3 BELLINI trial evaluating the drug for this treatment.

March 21st 2019

NCCN Panel Digs Into Reality of CAR T-Cell Reimbursement

Mary Caffrey

A panel during the opening day of the 2019 National Comprehensive Cancer Network Annual Conference examined the recent process for National Coverage Determination for chimeric antigen receptor (CAR) T-cell therapy and what it means for the future of innovative treatments.

March 14th 2019

Will CMS' CAR T-Cell Therapy Payment Plan Leave Out Community Practices?

Mary Caffrey

There is concern among stakeholder groups that references to “hospital” could mean that community practices would be unable to be reimbursed by Medicare under a proposed National Coverage Determination.

March 13th 2019

Once-Weekly Carfilzomib as Safe, Effective as Twice-Weekly Treatment in Newly Diagnosed MM

Jaime Rosenberg

Pooled data from 2 studies revealed that once-weekly administration of 70 mg/m2 of carfilzomib is as safe and effective in newly diagnosed multiple myeloma (MM) as twice-weekly administration of 36 mg/m2 of the treatment while also providing a more convenient treatment schedule.

March 8th 2019

Addressing Disparities in End-of-Life Care in Blood Cancers

Laura Joszt, MA

While use of palliative care at the end of life has increased, disparities remain, and not all patients who are terminally ill with blood cancers are having discussions about their goals of care at the end of life.

March 6th 2019

Carfilzomib Regimen Results in Longer Time to Next Treatment, Improved Survival in RRMM

Jaime Rosenberg

Compared with other drug regimens, a carfilzomib-based regimen resulted in longer time to next treatment, as well as longer overall survival and improved 24-month survival, among patients with relapsed or refractory multiple myeloma (RRMM).

March 2nd 2019

Patients With RRMM Are Undertreated With Carfilzomib in the Real World, Study Finds

Laura Joszt, MA

Since carfilzomib was approved at a 27 mg/m2 twice-weekly dose, it has since been optimized at 56 mg/m2 twice-weekly and a recent study found benefits of a 70 mg/m2 once-weekly dose. However, most patients are still treated with the original approval dosage, suggesting they might be undertreated.

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