- Center on Health Equity and Access
- Clinical
- Health Care Cost
- Health Care Delivery
- Insurance
- Policy
- Technology
- Value-Based Care
Dr Oliver Dorigo on Identified Biomarkers in Gynecologic Malignancies
We have a number of biomarkers that we have shown are associated with a better response to certain new therapies, said Oliver Dorigo, MD, PhD, associate professor, obstetrics and gynecology, Stanford University Medical Center.
We have a number of biomarkers that we have shown are associated with a better response to certain new therapies, said Oliver Dorigo, MD, PhD, associate professor, obstetrics and gynecology, Stanford University Medical Center.
Transcript
What biomarkers have you identified to determine prognosis and treatment outcomes in gynecologic malignancies?
We have a number of biomarkers that we have shown are associated with a better response to certain new therapies. PARP inhibitors, for example, work the best in those patients that have either germline mutations of BRCA1 and BRCA2 or those mutations only in the tumor tissue. It’s particularly true in ovarian cancer, where we have the most experience.
We also know that certain ovarian cancers have a certain degree of defects and repair mechanisms that the cell uses to repair DNA damage. If these mechanisms are dysfunctional, then patients, again, are more likely to respond to PARP inhibitors. We call this a so-called homologous recombination deficiency score, which is a measure or a biomarker that predicts the response to PARP inhibitors, at least to some extent.
In immunotherapy, biomarkers relate mostly to what we call microsatellite instability, which does increase the probability of a patient responding to immune-checkpoint inhibition.
ATS 2024: Bridging the Past, Present, and Future of Respiratory Care
May 16th 2024The application of artificial intelligence in medicine is anticipated as a highlight of ATS 2024, with sessions exploring its applications in research, radiological interpretation, and pediatric pulmonology.
Read More
Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
Listen
Oncology Onward: A Conversation With Penn Medicine's Dr Justin Bekelman
December 19th 2023Justin Bekelman, MD, director of the Penn Center for Cancer Care Innovation, sat with our hosts Emeline Aviki, MD, MBA, and Stephen Schleicher, MD, MBA, for our final episode of 2023 to discuss the importance of collaboration between academic medicine and community oncology and testing innovative cancer care delivery in these settings.
Listen
Posters Characterize DMD Caregiver Experiences, Impact of Gene Therapy on Caregiving Demands
May 10th 2024Posters presented at the ISPOR—The Professional Society for Health Economics and Outcomes Research meeting explored Duchenne muscular dystrophy (DMD) caregiver experiences and gene therapy’s impact on work opportunities for caregivers.
Read More
