The most-read content from the 2023 American Society of Hematology Annual Meeting and Exposition included the latest in treating hematologic malignancies, the hope brought by novel therapy strategies, and the potential for artificial intelligence to improve diagnostic accuracy.
The most-read content from the 2023 American Society of Hematology Annual Meeting and Exposition included the latest in treating hematologic malignancies, the hope brought by novel therapy strategies, and the potential for artificial intelligence (AI) to improve diagnostic accuracy.
Check out the rest of our ASH 2023 coverage here.
5. Is Genome Editing the Next Step in Immunotherapy Innovation? Experts Think So
In recent years, chimeric antigen receptor (CAR) T-cell therapies have brought hope to patients with certain hematologic cancers that previously had few, if any, effective treatment options. In a presentation at ASH 2023, experts in the field expressed optimism that CAR T-cell therapy is just the beginning of what can be done with cellular immunotherapy. With technologies such as CRISPR genome editing carrying potential to improve immunotherapy efficacy, the hope is that ongoing research will translate to clinical utility in the near future.
4.Cellular Therapies in Lymphoma Bring Hope, but Optimizing Their Use Remains a Challenge
Cellular therapies such as CAR T-cell therapies have changed the landscape of hematologic cancer treatment in recent years, but a roster of experts at ASH 2023 noted that the best way to use and sequence these therapies is still not entirely understood. Identifying prognostic factors for cellular therapy response, determining the role of bridging therapy, and managing aggressive lymphomas following CAR T-cell therapy failure were key questions discussed by presenters.
3.Results Show Strong Responses for Brentuximab Vedotin Plus Nivolumab Combo in Patients With cHL
Data from 2 abstracts at ASH 2023 demonstrated promising responses among patients treated with brentuximab vedotin plus nivolumab in a 4-drug regimen for classical Hodgkin lymphoma (cHL). Results showed 100% of patients with early-stage cHL were still progression-free at 12 months. Among those with advanced disease, 88% remained progression-free at 24 months.
2. Dr Andrew Srisuwananukorn on the Potential for AI in Differentiating prePMF and ET
AI has emerged as a potentially useful tool across numerous clinical tasks, and an abstract presented at ASH 2023 showed an algorithm capable of differentiating between primary myelofibrosis (prePMF) and essential thrombocythemia (ET) with 92.3% accuracy. AI-based decision support tools may be especially helpful for clinicians who do not see prePMF or ET frequently, lead author Andrew Srisuwananukorn, MD, of Ohio State University Comprehensive Cancer Center, told The American Journal of Managed Care® in this video interview.
1. ALPINE: After 39 Months, Zanubrutinib Keeps Its PFS Edge Over Ibrutinib in R/R CLL, Especially for High-Risk Patients
At 39 months of follow-up, zanubrutinib demonstrated a 32% improvement in progression-free survival compared with ibrutinib in patients with for chronic lymphocytic leukemia (CLL) or small lymphocytic leukemia after 1 prior line of treatment, according to findings from the phase 3 ALPINE trial presented at ASH 2023. During the presentation, Jennifer Brown, MD, PhD, of Dana-Farber Cancer Institute, explained that zanubrutinib has higher concentration ratios and thus offers more complete inhibition of BTK compared with ibrutinib, and that it produces fewer off-target effects.
Initiating BP Medication Linked to Higher Fall, Fracture Risks in Nursing Home Residents
May 2nd 2024Among over 60,000 nursing home residents who initiated antihypertensive medication, rates of excess fractures due to falls per 100 person-years were as high as 5 among certain patient groups, such as those with dementia and high blood pressure (BP).
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Latest Advances and Updates of Treatment in the Real World at AUA
May 1st 2024The annual meeting of the American Urological Association (AUA) not only presents the newest therapies coming out but showcases the latest in how treatments are being used in the real world, said Stephen Freedland, MD, of Cedars Sinai.
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