This year’s most-read articles on multiple sclerosis (MS) explored the emergence of new medications, modes of therapy, and predictive tools in the study of MS.
The top 5 most-read multiple sclerosis (MS) articles and interviews on AJMC.com this year included news on the progress of treatment options in MS, expert insights into the new mechanisms at work in novel treatments, and biomarker discoveries to better anticipate patient outcomes.
Here are the top-5 MS pieces of 2023.
5. Cognitive Benefits in Multiple Sclerosis Seen After Transcranial Current Stimulation
One of the core symptoms of MS is cognitive impairment. To broaden the scope of treatment for these effects, this study evaluated frontal theta-transcranial alternating current stimulation and found that a single session could improve cognitive function in patients with MS. This article was originally published by NeurologyLive®.
4. Internet-Based CBT Effective for Treating MS-Related Depression, Study Finds
Depression is a very common symptom that arises in patients who are enduring inflammatory or neurological disorders. In a phase 3 trial, researchers observed the impact of stand-alone and therapist-guided therapy done remotely and found that internet-based cognitive behavioral therapy (CBT) was an effective method for combatting depressive symptoms for patients with MS.
3. Dr Erik Wallstroem and Tom Snow Highlight New MS Treatments Aimed at Smoldering Inflammation
In this interview, Erik Wallstroem, MD, PhD, global head of development, neurology and ophthalmology, and Tom Snow, global franchise head, neurology and rare blood disorders, both at Sanofi, discussed the recent development and approval of 3 novel treatments in MS: tolebrutinab, frexalimab, and SAR443820 (RIPK1i). The designs of these therapies aim to infiltrate the central nervous system and affect smoldering inflammation at its source.
2. Oral N-Acetylglucosamine Treatment Benefits Management of MS, Study Finds
Directly addressing the inflammation present in patients with MS is not enough to stimulate necessary myelin repair. N-acetylglucosamine has emerged as a promising supplement in MS treatment. This study demonstrated its efficacy in tackling and improving patients’ abilities to manage inflammation and immune responses stemming from their MS.
1. Timing of Neurofilament Light Changes May Predict Multiple Sclerosis Worsening
In this study, neurofilament light changes exhibited promise as a biomarker of progression in MS. Researchers found that elevations in neurofilament light levels were linked to patterns of disability worsening in patients with MS. These changes were predictive of disease worsening approximately 1 year in advance. This article was originally published by NeurologyLive.
Study Highlights Significant Increases in Utilization, Spending on DMD Drugs in Medicaid
May 17th 2024The findings add to recent research on the growing utilization, expenditure, and prices of Duchenne muscular dystrophy (DMD) therapies in the current landscape, an area health care policy could potentially address.
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Frameworks for Advancing Health Equity: Urban Health Outreach
May 9th 2024In the series debut episode of "Frameworks for Advancing Health Equity," Mary Sligh, CRNP, and Chelsea Chappars, of Allegheny Health Network, explain how the Urban Health Outreach program aims to improve health equity for individuals experiencing homelessness.
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Perioperative Nivolumab Boosts NSCLC Survival: CheckMate 77T Trial
May 16th 2024This interim analysis of the CheckMate 77T trial, outcomes were compared between adult patients receiving neoadjuvant nivolumab plus chemotherapy or neoadjuvant chemotherapy plus placebo for resectable non–small cell lung cancer (NSCLC).
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